⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27700371 | 0.69 | — | — | |
| SCHEMBL10987236 | 0.68 | — | — | |
| SCHEMBL146698 | 0.68 | — | — | |
| SCHEMBL1661731 | 0.68 | — | — | |
| SCHEMBL272130 | 0.68 | — | — | |
| SCHEMBL30519269 | 0.68 | — | — | |
| SCHEMBL8091109 | 0.68 | — | — | |
| SCHEMBL3223865 | 0.67 | — | — | |
| Iodide SCHEMBL11482211 | 0.67 | — | — | |
| SCHEMBL3782742 | 0.67 | HDAC8 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836602-B1 | FUNGICIDAL PYRIMIDINONES | DU PONT (US) | 2002-01-30 | — | — | EP | claimed |
| US-10682330-B2 | Method for producing liposome encapsulating paclitaxel monoglycoside and/or docetaxel monoglycoside | ENSUIKO SUGAR REFINING CO., LTD. (JP) | 2020-06-16 | — | — | US | disclosed |
| EP-2829273-B1 | METHOD FOR PRODUCING LIPOSOME ENCAPSULATING PACLITAXEL MONOGLYCOSIDE AND/OR DOCETAXEL MONOGLYCOSIDE | ENSUIKO SUGAR REFINING (JP) | 2018-08-29 | — | — | EP | disclosed |
| EP-3078662-A1 | PYRIDIN-2-YL-AMINO-1,2,4-THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS | Array Biopharma, Inc. (US) | 2016-10-12 | — | — | EP | disclosed |
| US-20160256566-A2 | METHOD FOR PRODUCING LIPOSOME ENCAPSULATING PACLITAXEL MONOGLYCOSIDE AND/OR DOCETAXEL MONOGLYCOSIDE | ENSUIKO SUGAR REFINING CO., LTD. (JP) | 2016-09-08 | — | — | US | disclosed |
| EP-2727910-B1 | Pyridin-2-yl-thiourea and Pyridin-2-yl-amine derivatives as intermediates for the preparation of Pyridin-2yl-amino-1,2,4-thiadiazole glucokinase activators | ARRAY BIOPHARMA INC (US) | 2016-03-16 | — | — | EP | disclosed |
| US-9079890-B2 | Intermediates for the preparation of pyridin-2-yl-amino-1,2,4-thiadiazole derivatives | ARRAY BIOPHARMA INC. (US) | 2015-07-14 | — | — | US | disclosed |
| US-20150057448-A1 | INTERMEDIATES FOR THE PREPARATION OF PYRIDIN-2-YL-AMINO-1,2,4-THIADIAZOLE DERIVATIVES | ARRAY BIOPHARMA, INC. | 2015-02-26 | — | — | US | disclosed |
| US-20150056270-A1 | METHOD FOR PRODUCING LIPOSOME ENCAPSULATING PACLITAXEL MONOGLYCOSIDE AND/OR DOCETAXEL MONOGLYCOSIDE | HAMADA HIROKI (JP) | 2015-02-26 | — | — | US | disclosed |
| EP-2829273-A1 | METHOD FOR PRODUCING LIPOSOME ENCAPSULATING PACLITAXEL MONOGLYCOSIDE AND/OR DOCETAXEL MONOGLYCOSIDE | Ensuiko Sugar Refining Co.Ltd. (JP) | 2015-01-28 | — | — | EP | disclosed |
| US-20100204240-A1 | Pyridin-2-YL-Amino-1, 2, 4-Thiadiazole Derivatives as Glucokinase Activators for the Treatment of Diabetes Mellitus | ARRAY BIOPHARMA INC. (US) | 2010-08-12 | — | — | US | disclosed |
| EP-2209778-A1 | PYRIDIN-2 -YL-AMINO-I, 2, 4 -THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS | Array Biopharma, Inc. (US) | 2010-07-28 | — | — | EP | disclosed |
| US-20100113759-A1 | PROPARGYL SUBSTITUTED NUCLEOSIDE COMPOUNDS AND METHODS | Life Technologies Corporation (US) | 2010-05-06 | — | — | US | disclosed |
| US-20100113759-A1 | PROPARGYL SUBSTITUTED NUCLEOSIDE COMPOUNDS AND METHODS | Life Technologies Corporation (US) | 2010-05-06 | — | — | US | disclosed |
| WO-2009058911-A2 | PREPARATION AND ISOLATION OF 5' CAPPED MRNA | APPLIED BIOSYSTEMS INC. (US) | 2009-05-07 | — | — | WO | disclosed |
| WO-2009042435-A1 | PYRIDIN-2 -YL-AMINO-I, 2, 4 -THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS | ARRAY BIOPHARMA INC. (US) | 2009-04-02 | — | — | WO | disclosed |
| US-5093505-A | Pyranone and pyran-thione derivatives | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1992-03-03 | — | — | US | disclosed |
| EP-0377031-A1 | 5-DEAZA-5,7-DISUBSTITUTED-AMINOPTERIN ANALOGUES | Sloan-Kettering Institute For Cancer Research (US) | 1990-07-11 | — | — | EP | disclosed |
| WO-1990000172-A1 | 5-DEAZA-5,7-DISUBSTITUTED-AMINOPTERIN ANALOGUES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-01-11 | — | — | WO | disclosed |
| EP-0069872-A2 | New cephem compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-19 | — | — | EP | disclosed |