Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | GCK | P35557 | 12/20 | 0.42 |
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2642103 | 0.90 | KCNH2 (0.61) | KCNH2GCKCNR2 | |
| SCHEMBL14423117 | 0.90 | KCNH2 (0.61) | KCNH2GCKCNR2 | |
| SCHEMBL2642403 | 0.88 | KCNH2 (0.45) | KCNH2GCKCNR2GRM5CNR1 | |
| SCHEMBL2642041 | 0.88 | KCNH2 (0.44) | KCNH2GCK | |
| SCHEMBL14423119 | 0.88 | KCNH2 (0.44) | KCNH2GCK | |
| SCHEMBL14423120 | 0.88 | KCNH2 (0.45) | KCNH2GCKCNR2GRM5CNR1 | |
| SCHEMBL14436824 | 0.87 | KCNH2 (0.59) | KCNH2GCKCNR2CNR1 | |
| SCHEMBL2642204 | 0.87 | KCNH2 (0.59) | KCNH2GCKCNR2CNR1 | |
| SCHEMBL14423107 | 0.87 | KCNH2 (0.59) | KCNH2GCKCNR2CNR1 | |
| SCHEMBL14423118 | 0.87 | KCNH2 (0.43) | KCNH2GCKCNR2GRM5CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501815-B1 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2006-11-22 | — | — | EP | disclosed |