Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 7/20 | 0.52 |
| ▸ | FEN1 | P39748 | 6/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PIEZO1 | Q92508 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | TERT | O14746 | 3/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652043 | 0.86 | ALOX5AP (0.42) | ALOX5APFEN1GAANPC1RAB9A | |
| SCHEMBL4028337 | 0.82 | ALOX5AP (0.54) | ALOX5APFEN1NPC1RAB9APIM1 | |
| SCHEMBL27795040 | 0.81 | NPC1 (0.46) | ALOX5APFEN1GAANPC1RAB9A | |
| SCHEMBL21044403 | 0.79 | FEN1 (0.57) | ALOX5APFEN1NPC1RAB9APIM1 | |
| SCHEMBL5077785 | 0.77 | ALOX5AP (0.47) | ALOX5APFEN1NPC1RAB9AMEN1 | |
| SCHEMBL29674848 | 0.77 | ALOX5AP (0.47) | ALOX5APFEN1NPC1RAB9AMEN1 | |
| SCHEMBL15915495 | 0.75 | FEN1 (0.86) | ALOX5APFEN1 | |
| SCHEMBL31140243 | 0.74 | ALOX5AP (0.55) | ALOX5APFEN1NPC1RAB9APIM1 | |
| SCHEMBL16640380 | 0.74 | ALOX5AP (0.55) | ALOX5APFEN1NPC1RAB9APIM1 | |
| SCHEMBL27752919 | 0.73 | ALOX5AP (0.44) | ALOX5APFEN1GAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1381606-A1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2004-01-21 | — | — | EP | disclosed |
| WO-2002074773-A1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2002-09-26 | — | — | WO | disclosed |