Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.50 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1084250 | 0.76 | CYP2D6 (0.57) | ABCG2ABCB1ABCC1TDP1CYP1A2 | |
| SCHEMBL16404333 | 0.74 | METAP1 (0.61) | METAP1ABCG2MAOAMAOBCYP1A2 | |
| SCHEMBL384799 | 0.74 | METAP1 (0.61) | METAP1ABCG2MAOAMAOBACP1 | |
| SCHEMBL4496945 | 0.73 | NPC1 (0.49) | METAP1CYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL3461416 | 0.72 | MAPT (0.59) | METAP1ABCG2MAPK1PDE5AMEN1 | |
| SCHEMBL23723282 | 0.72 | METAP1 (0.50) | METAP1ABCG2MAOAMAOBPDE4A | |
| SCHEMBL7431547 | 0.72 | PDE5A (0.66) | ABCG2ABCB1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9719995 | 0.72 | ABCB1 (0.42) | ABCG2ABCB1ABCC1TDP1HSD17B10 | |
| SCHEMBL25463096 | 0.72 | MEN1 (0.57) | METAP1ABCG2CYP1A2ACP1PDE5A | |
| SCHEMBL17275213 | 0.72 | METAP1 (0.57) | METAP1ABCG2CYP1A2ACP1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339866-A1 | Quinazoline compounds and the use thereof in the treatment of cancer | TroBio Therapeutics Pty Ltd (AU) | 2023-10-26 | — | — | US | disclosed |
| EP-4100395-A1 | QUINAZOLINE COMPOUNDS AND THE USE THEREOF IN THE TREATMENT OF CANCER | Trobio Therapeutics Pty Ltd (AU) | 2022-12-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339866-A1 | Quinazoline compounds and the use thereof in the treatment of cancer | NQO2, TP53, ABL1 | METAP1 3734/4885ABCG2 147/4885ABCB1 99/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.