Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 3/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 5/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.40 |
| ▸ | WNT1 | P04628 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | PRKDC | P78527 | 2/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26599197 | 0.91 | MAPK1 (0.44) | TYK2JAK1MAP3K5GSK3BDYRK1A | |
| SCHEMBL26599203 | 0.91 | MAPK1 (0.44) | TYK2JAK1MAP3K5GSK3BDYRK1A | |
| SCHEMBL25259412 | 0.89 | MAP3K5 (0.51) | TYK2JAK1MAP3K5GSK3BDYRK1A | |
| SCHEMBL31185798 | 0.76 | TYK2 (0.51) | TYK2JAK1MAP3K5DYRK1AL3MBTL1 | |
| SCHEMBL26599153 | 0.76 | TYK2 (0.51) | TYK2JAK1MAP3K5DYRK1AL3MBTL1 | |
| SCHEMBL30633549 | 0.76 | PIK3CB (0.51) | TYK2JAK1MAPK1ABL1L3MBTL1 | |
| SCHEMBL26599818 | 0.71 | TYK2 (0.47) | TYK2JAK1DYRK1ACCNT1CDK4 | |
| SCHEMBL31185868 | 0.68 | TYK2 (0.47) | TYK2JAK1MAP3K5GSK3BDYRK1A | |
| SCHEMBL26599338 | 0.68 | TYK2 (0.47) | TYK2JAK1MAP3K5GSK3BDYRK1A | |
| SCHEMBL26599329 | 0.68 | TYK2 (0.47) | TYK2JAK1MAP3K5GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114075221-B | Substituted heteroaryl compounds, compositions and uses thereof | 广东东阳光药业股份有限公司 | 2024-08-23 | — | — | CN | disclosed |
| US-20230339977-A1 | SUBSTITUTED HETEROARYL COMPOUND, AND COMPOSITION AND APPLICATION THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2023-10-26 | — | — | US | disclosed |
| CN-114075221-A | Substituted heteroaryl compounds, compositions and uses thereof | 广东东阳光药业有限公司 | 2022-02-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339977-A1 | SUBSTITUTED HETEROARYL COMPOUND, AND COMPOSITION AND APPLICATION THEREOF | TYK2, JAK1, JAK3 | TYK2 1/4885JAK1 2/4885MAP3K5 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.