Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2659930 | 1.00 | HSD17B3 (0.43) | HSD17B3MAPTRAB9AL3MBTL1NAPRT | |
| SCHEMBL2659932 | 1.00 | HSD17B3 (0.43) | HSD17B3MAPTRAB9AL3MBTL1NAPRT | |
| SCHEMBL2271956 | 0.87 | HSD17B3 (0.56) | HSD17B3MAPTRAB9AL3MBTL1NAPRT | |
| SCHEMBL2270818 | 0.86 | HSD17B3 (0.57) | HSD17B3MAPTRAB9AL3MBTL1NAPRT | |
| SCHEMBL2269514 | 0.85 | CYP3A4 (0.39) | FAAHLTB4RDGAT1LMNA | |
| SCHEMBL2269524 | 0.85 | CYP3A4 (0.39) | FAAHLTB4RDGAT1LMNA | |
| SCHEMBL2269519 | 0.85 | CYP3A4 (0.39) | FAAHLTB4RDGAT1LMNA | |
| SCHEMBL20372049 | 0.83 | HSD17B3 (0.54) | HSD17B3MAPTRAB9AL3MBTL1NAPRT | |
| SCHEMBL11899972 | 0.77 | NAPRT (0.56) | HSD17B3MAPTRAB9AL3MBTL1NAPRT | |
| SCHEMBL11900194 | 0.77 | CYP3A4 (0.41) | MAPTNAPRTDGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |