Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATP4A | P20648 | 1/20 | 0.37 |
| ▸ | ATP4B | P51164 | 1/20 | 0.37 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31517782 | 0.81 | HTT (0.47) | SMN1; SMN2HTTSTAT3L3MBTL1MAPT | |
| SCHEMBL31517915 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2HTTSTAT3L3MBTL1MAPT | |
| SCHEMBL26601636 | 0.78 | HTT (0.44) | SMN1; SMN2HTTSTAT3L3MBTL1MAPT | |
| SCHEMBL26601883 | 0.78 | HTT (0.44) | SMN1; SMN2HTTSTAT3L3MBTL1MAPT | |
| SCHEMBL30593159 | 0.78 | HTT (0.44) | SMN1; SMN2HTTSTAT3L3MBTL1MAPT | |
| SCHEMBL26601758 | 0.78 | SMN1; SMN2 (0.46) | SMN1; SMN2HTTSTAT3L3MBTL1MAPT | |
| SCHEMBL26601820 | 0.77 | HTT (0.54) | SMN1; SMN2HTTSTAT3L3MBTL1MAPT | |
| SCHEMBL4781292 | 0.77 | HTT (0.54) | SMN1; SMN2HTTSTAT3L3MBTL1MAPT | |
| SCHEMBL26601861 | 0.75 | PTGDR2 (0.49) | SMN1; SMN2HTTSTAT3L3MBTL1MAPT | |
| SCHEMBL26601848 | 0.75 | HTT (0.51) | SMN1; SMN2HTTSTAT3L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4511117-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | Vertex Pharmaceuticals Incorporated (US) | 2025-02-26 | — | — | EP | disclosed |
| WO-2023205465-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-10-26 | — | — | WO | disclosed |