Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.48 |
| ▸ | IKZF3 | Q9UKT9 | 11/20 | 0.48 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | IL1B | P01584 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26609496 | 0.89 | CRBN (0.47) | CRBNIKZF3IKZF2DDB1DRD2 | |
| SCHEMBL26608888 | 0.87 | CRBN (0.49) | CRBNIKZF3IKZF2DDB1DRD2 | |
| SCHEMBL26609685 | 0.86 | IKZF2 (0.49) | CRBNIKZF3IKZF2DDB1IKZF1 | |
| SCHEMBL26610146 | 0.85 | CRBN (0.48) | CRBNIKZF3IKZF2DDB1DRD2 | |
| SCHEMBL26609175 | 0.85 | CRBN (0.48) | CRBNIKZF3IKZF2DDB1DRD2 | |
| SCHEMBL26608679 | 0.85 | CRBN (0.48) | CRBNIKZF3IKZF2DDB1DRD2 | |
| SCHEMBL26609036 | 0.85 | CRBN (0.63) | CRBNIKZF3IKZF2DDB1DRD2 | |
| SCHEMBL26610409 | 0.84 | CRBN (0.49) | CRBNIKZF3IKZF2DDB1DRD2 | |
| SCHEMBL26608779 | 0.84 | CRBN (0.60) | CRBNIKZF3IKZF2DDB1DRD2 | |
| SCHEMBL26610621 | 0.84 | CRBN (0.52) | CRBNIKZF3IKZF2IKZF1CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339904-A1 | ISOINDOLINONES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. | 2023-10-26 | — | — | US | claimed |
| US-20230339904-A1 | ISOINDOLINONES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. | 2023-10-26 | — | — | US | disclosed |
| US-20230339904-A1 | ISOINDOLINONES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. | 2023-10-26 | — | — | US | disclosed |
| US-20230339904-A1 | ISOINDOLINONES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. | 2023-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339904-A1 | ISOINDOLINONES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | CSNK1A1, CSNK1D, CSNK1G1 | CRBN 2723/4885IKZF3 973/4885IKZF2 2228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.