Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKZF1 | Q13422 | 3/20 | 0.51 |
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 15/20 | 0.51 |
| ▸ | IKZF3 | Q9UKT9 | 10/20 | 0.51 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 3/20 | 0.46 |
| ▸ | IL1B | P01584 | 3/20 | 0.46 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26609406 | 0.90 | IKZF2 (0.65) | IKZF1IKZF2CRBNIKZF3DDB1 | |
| SCHEMBL26610689 | 0.88 | IKZF1 (0.58) | IKZF1IKZF2CRBNIKZF3DDB1 | |
| SCHEMBL26608971 | 0.88 | IKZF1 (0.53) | IKZF1IKZF2CRBNIKZF3DDB1 | |
| SCHEMBL26609879 | 0.88 | IKZF1 (0.55) | IKZF1IKZF2CRBNIKZF3DDB1 | |
| SCHEMBL26609275 | 0.88 | IKZF1 (0.53) | IKZF1IKZF2CRBNIKZF3DDB1 | |
| SCHEMBL26610722 | 0.87 | IKZF2 (0.59) | IKZF1IKZF2CRBNIKZF3DDB1 | |
| SCHEMBL26610169 | 0.87 | CRBN (0.54) | IKZF1IKZF2CRBNIKZF3DDB1 | |
| SCHEMBL26610813 | 0.87 | IKZF1 (0.56) | IKZF1IKZF2CRBNIKZF3DDB1 | |
| SCHEMBL26609911 | 0.86 | CRBN (0.52) | IKZF1IKZF2CRBNIKZF3DDB1 | |
| SCHEMBL26609067 | 0.85 | IKZF2 (0.53) | IKZF1IKZF2CRBNIKZF3DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339904-A1 | ISOINDOLINONES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. | 2023-10-26 | — | — | US | claimed |
| US-20230339904-A1 | ISOINDOLINONES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. | 2023-10-26 | — | — | US | disclosed |
| US-20230339904-A1 | ISOINDOLINONES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. | 2023-10-26 | — | — | US | disclosed |
| US-20230339904-A1 | ISOINDOLINONES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. | 2023-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339904-A1 | ISOINDOLINONES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | CSNK1A1, CSNK1D, CSNK1G1 | IKZF1 2053/4885IKZF2 2228/4885CRBN 2723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.