Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | GALR3 | O60755 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | KCNT1 | Q5JUK3 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26613937 | 0.81 | KCNT1 (0.53) | TRPV1ALDH1A1CYP3A4HSD17B10POLB | |
| SCHEMBL26613914 | 0.79 | KCNT1 (0.47) | TRPV1ALDH1A1CYP3A4HSD17B10POLB | |
| SCHEMBL26613961 | 0.78 | KCNT1 (0.56) | TRPV1POLBKCNT1KCNQ1KCNH2 | |
| SCHEMBL26613909 | 0.77 | KCNT1 (0.47) | TRPV1ALDH1A1CYP3A4HSD17B10POLB | |
| SCHEMBL26613915 | 0.76 | KCNT1 (0.52) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL26613900 | 0.76 | KCNT1 (0.52) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL26613995 | 0.72 | KCNT1 (0.56) | TRPV1POLBKCNT1KCNQ1KCNH2 | |
| SCHEMBL26617060 | 0.71 | KCNT1 (0.58) | POLBKCNT1KCNQ1KCNH2CACNA1C | |
| SCHEMBL15646412 | 0.69 | NAMPT (0.61) | CYP3A4 | |
| SCHEMBL26739478 | 0.69 | KCNT1 (0.53) | TRPV1ALDH1A1CYP3A4HSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023211854-A1 | KCNT1 INHIBITORS COMPRISING A THIAZOLE CORE AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-11-02 | — | — | WO | disclosed |