Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 14/20 | 0.56 |
| ▸ | KIF18A | Q8NI77 | 6/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30681908 | 1.00 | SCN10A (0.56) | SCN10AKIF18ANR1I2CACNA1C | |
| SCHEMBL26617595 | 0.94 | SCN10A (0.56) | SCN10AKIF18ANR1I2CACNA1C | |
| SCHEMBL30681923 | 0.94 | SCN10A (0.56) | SCN10AKIF18ANR1I2CACNA1C | |
| SCHEMBL30681962 | 0.94 | SCN10A (0.56) | SCN10AKIF18ANR1I2CACNA1C | |
| SCHEMBL26617714 | 0.94 | SCN10A (0.56) | SCN10AKIF18ANR1I2CACNA1C | |
| SCHEMBL30681898 | 0.91 | SCN10A (0.67) | SCN10ANR1I2CACNA1C | |
| SCHEMBL26617823 | 0.91 | SCN10A (0.67) | SCN10ANR1I2CACNA1C | |
| SCHEMBL26617546 | 0.90 | SCN10A (0.65) | SCN10AKIF18ANR1I2CACNA1C | |
| SCHEMBL30682062 | 0.88 | SCN10A (0.56) | SCN10AKIF18ANR1I2CACNA1C | |
| SCHEMBL26617661 | 0.88 | SCN10A (0.54) | SCN10AKIF18ANR1I2CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023211990-A1 | BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA V1.8 FOR THE TREATMENT OF PAIN | SITEONE THERAPEUTICS, INC. (US) | 2023-11-02 | — | — | WO | disclosed |
| WO-2023211990-A1 | BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA V1.8 FOR THE TREATMENT OF PAIN | SITEONE THERAPEUTICS, INC. (US) | 2023-11-02 | — | — | WO | disclosed |