Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.30 |
| ▸ | ITGAV | P06756 | 1/20 | 0.30 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16508704 | 0.87 | JAK2 (0.54) | JAK2JAK1TYK2JAK3HPGD | |
| SCHEMBL16495293 | 0.86 | JAK2 (0.65) | JAK2JAK1TYK2JAK3HPGD | |
| SCHEMBL16495288 | 0.86 | JAK2 (0.53) | JAK2JAK1TYK2JAK3HPGD | |
| SCHEMBL16495160 | 0.85 | JAK2 (0.52) | JAK2JAK1TYK2JAK3HPGD | |
| SCHEMBL2668316 | 0.85 | JAK2 (0.52) | JAK2JAK1TYK2JAK3HPGD | |
| SCHEMBL16495285 | 0.85 | JAK2 (0.52) | JAK2JAK1TYK2JAK3HPGD | |
| SCHEMBL2661983 | 0.85 | JAK2 (0.49) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL9072745 | 0.84 | JAK2 (0.51) | JAK2JAK1TYK2JAK3HPGD | |
| SCHEMBL2661609 | 0.84 | JAK2 (0.49) | JAK2JAK1TYK2JAK3HPGD | |
| SCHEMBL2661978 | 0.83 | JAK2 (0.47) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2157859-A1 | INDAZOLE COMPOUNDS FOR ACTIVATING GLUCOKINASE | Takeda Pharmaceutical Company Limited (JP) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008156757-A1 | INDAZOLE COMPOUNDS FOR ACTIVATING GLUCOKINASE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-24 | — | — | WO | disclosed |