Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 18/20 | 0.76 |
| ▸ | GIPR | P48546 | 13/20 | 0.69 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2662071 | 1.00 | GCGR (0.76) | GCGRGIPRGPR119TRPM8 | |
| SCHEMBL2884133 | 0.88 | GCGR (0.79) | GCGRGIPR | |
| SCHEMBL2884135 | 0.88 | GCGR (0.79) | GCGRGIPR | |
| SCHEMBL2876976 | 0.87 | GCGR (0.69) | GCGRGIPRGPR119 | |
| SCHEMBL2659794 | 0.87 | GCGR (0.69) | GCGRGIPRGPR119 | |
| SCHEMBL2666538 | 0.84 | GCGR (0.69) | GCGRGIPRGPR119 | |
| SCHEMBL2661300 | 0.82 | GCGR (0.76) | GCGRGIPR | |
| SCHEMBL2661301 | 0.82 | GCGR (0.76) | GCGRGIPR | |
| SCHEMBL2881507 | 0.81 | GCGR (0.76) | GCGRGIPR | |
| SCHEMBL2881502 | 0.81 | GCGR (0.76) | GCGRGIPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1868985-A2 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | Merck & Co., Inc. (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006104826-A2 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 2006-10-05 | — | — | WO | disclosed |