Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 19/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1426495 | 0.81 | GCK (0.72) | GCKKCNH2HRH3 | |
| SCHEMBL1378945 | 0.81 | GCK (0.82) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL1427143 | 0.80 | GCK (0.70) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL1652701 | 0.80 | GCK (0.85) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL1427054 | 0.80 | GCK (0.85) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL2074563 | 0.79 | GCK (0.65) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL2075774 | 0.79 | GCK (0.65) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL2072486 | 0.79 | GCK (0.65) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL2656565 | 0.79 | GCK (0.64) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL1427220 | 0.79 | GCK (1.00) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086964-A2 | BENZOYL AMINO HETEROCYCLYL COMPOUNDS USEFUL IN THE TREATMENT OF A DISEASE MEDIATED THROUGH GLK | Astra Zeneca AB (SE) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008050101-A2 | BENZOYL AMINO HETEROCYCLYL COMPOUNDS USEFUL IN THE TREATMENT OF A DISEASE MEDIATED THROUGH GLK | ASTRAZENECA AB (SE) | 2008-05-02 | — | — | WO | disclosed |