Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.62 |
| ▸ | GCK | P35557 | 15/20 | 0.49 |
| ▸ | Q9HBH1 | 1/20 | 0.39 | |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2646751 | 1.00 | KCNH2 (0.62) | KCNH2GCKPDF | |
| SCHEMBL2647543 | 0.89 | KCNH2 (0.77) | KCNH2GCKPDF | |
| SCHEMBL2646158 | 0.89 | KCNH2 (0.77) | KCNH2GCKPDF | |
| SCHEMBL2662841 | 0.89 | KCNH2 (0.77) | KCNH2GCKPDF | |
| SCHEMBL2662851 | 0.89 | KCNH2 (0.59) | KCNH2GCK | |
| SCHEMBL2647153 | 0.89 | KCNH2 (0.59) | KCNH2GCK | |
| SCHEMBL2647156 | 0.89 | KCNH2 (0.59) | KCNH2GCK | |
| SCHEMBL2658202 | 0.88 | KCNH2 (0.63) | KCNH2GCK | |
| SCHEMBL2647063 | 0.88 | KCNH2 (0.63) | KCNH2GCK | |
| SCHEMBL2662847 | 0.87 | KCNH2 (0.80) | KCNH2GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7223868-B2 | Such as 2-(3-chloro-phenyl)-3-cyclopentyl-N-thiazol-2-yl-propionamide which increases insulin secretion in treatment of type II diabetes | HOFFMANN-LA ROCHE INC. (US) | 2007-05-29 | — | — | US | disclosed |
| US-7223868-B2 | Such as 2-(3-chloro-phenyl)-3-cyclopentyl-N-thiazol-2-yl-propionamide which increases insulin secretion in treatment of type II diabetes | HOFFMANN-LA ROCHE INC. (US) | 2007-05-29 | — | — | US | disclosed |
| US-6610846-B1 | Increase insulin secretion; type II diabetes; 2,3-Di-substituted N-heteroaromatic propionamides with 3- a phenyl group and 2- a methyl cycloalkyl ring; 3-cyclopentyl-2-(3,4-dichlorophenyl)-N-pyridazin-3-yl-propionamide | HOFFMAN-LA ROCHE INC. | 2003-08-26 | — | — | US | disclosed |
| US-6610846-B1 | Increase insulin secretion; type II diabetes; 2,3-Di-substituted N-heteroaromatic propionamides with 3- a phenyl group and 2- a methyl cycloalkyl ring; 3-cyclopentyl-2-(3,4-dichlorophenyl)-N-pyridazin-3-yl-propionamide | HOFFMAN-LA ROCHE INC. | 2003-08-26 | — | — | US | disclosed |