Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12678178 | 0.88 | GCK (0.57) | GCKKCNH2 | |
| SCHEMBL9892945 | 0.86 | GCK (0.63) | GCKKCNH2 | |
| SCHEMBL1107539 | 0.86 | GCK (0.63) | GCKKCNH2 | |
| SCHEMBL2664173 | 0.86 | GCK (0.59) | GCKKCNH2 | |
| SCHEMBL1107296 | 0.85 | GCK (0.62) | GCKKCNH2 | |
| SCHEMBL2664261 | 0.83 | SMN1; SMN2 (0.52) | GCK | |
| SCHEMBL13127407 | 0.81 | GCK (0.57) | GCKKCNH2 | |
| SCHEMBL9986967 | 0.78 | GCK (0.82) | GCK | |
| SCHEMBL9986970 | 0.78 | GCK (0.82) | GCK | |
| SCHEMBL2660511 | 0.77 | GCK (0.65) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7812048-B2 | Glucokinase activators and methods of using same | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-10-12 | — | — | US | disclosed |
| US-20090030046-A1 | NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME | BRISTOL-MYERS SQUIBB COMPANY | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030046-A1 | NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME | GCKR, GCK, HK1 | GCK 2/4885KCNH2 413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.