⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14656016 | 1.00 | — | — | |
| SCHEMBL1189333 | 0.95 | DPP4 (0.44) | — | |
| SCHEMBL2768507 | 0.95 | DPP4 (0.44) | — | |
| SCHEMBL389573 | 0.95 | DPP4 (0.44) | — | |
| SCHEMBL8612552 | 0.93 | DPP4 (0.46) | — | |
| SCHEMBL5891316 | 0.93 | DPP4 (0.46) | — | |
| Hydrochloric Acid SCHEMBL4502967 | 0.93 | DPP4 (0.43) | — | |
| Hydrochloric Acid SCHEMBL9653875 | 0.93 | DPP4 (0.43) | — | |
| SCHEMBL856280 | 0.93 | DPP4 (0.46) | — | |
| SCHEMBL16935735 | 0.93 | DPP4 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250282768-A1 | PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2025-09-11 | — | — | US | disclosed |
| EP-4522607-A1 | PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF-kB INDUCING KINASE | JANSSEN Pharmaceutica NV (BE) | 2025-03-19 | — | — | EP | disclosed |
| CN-119317626-A | Pyrrolidone derivatives as inhibitors of NF- κb-induced kinase | 詹森药业有限公司 | 2025-01-14 | — | — | CN | disclosed |
| WO-2023217851-A1 | PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF-κB INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-16 | — | — | WO | disclosed |