Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 4/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | STK4 | Q13043 | 1/20 | 0.35 |
| ▸ | STK3 | Q13188 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.35 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30622371 | 1.00 | BTK (0.41) | BTKEGFRMAPK8MAPK9ITK | |
| SCHEMBL26644870 | 0.93 | LIMK1 (0.37) | BTKEGFRMAPK8MAPK9ITK | |
| SCHEMBL30622420 | 0.93 | LIMK1 (0.37) | BTKEGFRMAPK8MAPK9ITK | |
| SCHEMBL26645202 | 0.90 | EGFR (0.45) | BTKEGFRITKJAK3CLK2 | |
| SCHEMBL30622939 | 0.90 | EGFR (0.45) | BTKEGFRITKJAK3CLK2 | |
| SCHEMBL30622396 | 0.89 | EGFR (0.36) | BTKEGFRMAPK9JAK3JAK2 | |
| SCHEMBL30622307 | 0.88 | JAK3 (0.44) | EGFRJAK3JAK2LRRK2STK4 | |
| SCHEMBL26644961 | 0.88 | JAK3 (0.44) | EGFRJAK3JAK2LRRK2STK4 | |
| SCHEMBL30622354 | 0.86 | BTK (0.38) | BTKEGFRITKJAK3JAK2 | |
| SCHEMBL30622315 | 0.85 | JAK3 (0.33) | BTKEGFRITKJAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023213882-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | WO | disclosed |