Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.98 |
| ▸ | HTT | P42858 | 4/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.98 |
| ▸ | MERTK | Q12866 | 2/20 | 0.71 |
| ▸ | RAD52 | P43351 | 6/20 | 0.70 |
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | PGK1 | P00558 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | PAK4 | O96013 | 1/20 | 0.62 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.62 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26646013 | 0.87 | MERTK (0.87) | TAAR1HTTKDM4EMERTKRAD52 | |
| SCHEMBL8889167 | 0.86 | NPY5R (0.76) | TAAR1HTTKDM4EMERTKSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8907425 | 0.85 | HTT (0.75) | TAAR1HTTKDM4EMERTKSMN1; SMN2 | |
| SCHEMBL8891851 | 0.85 | NPY5R (0.78) | TAAR1HTTKDM4EMERTKSMN1; SMN2 | |
| SCHEMBL23747980 | 0.84 | HTT (0.72) | TAAR1HTTKDM4EMERTKRAD52 | |
| SCHEMBL30125191 | 0.84 | HTT (0.72) | TAAR1HTTKDM4EMERTKRAD52 | |
| SCHEMBL23748458 | 0.84 | TAAR1 (0.97) | TAAR1HTTKDM4EMERTKRAD52 | |
| SCHEMBL10031968 | 0.84 | TAAR1 (0.98) | TAAR1HTTKDM4EMERTKRAD52 | |
| Hydrochloric Acid SCHEMBL8899399 | 0.83 | NPY5R (0.76) | TAAR1HTTKDM4EMERTKSMN1; SMN2 | |
| SCHEMBL8889361 | 0.83 | KDM4E (0.70) | TAAR1HTTKDM4EMERTKSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339866-A1 | Quinazoline compounds and the use thereof in the treatment of cancer | TroBio Therapeutics Pty Ltd (AU) | 2023-10-26 | — | — | US | disclosed |
| US-20230339866-A1 | Quinazoline compounds and the use thereof in the treatment of cancer | TroBio Therapeutics Pty Ltd (AU) | 2023-10-26 | — | — | US | disclosed |
| EP-4100395-A1 | QUINAZOLINE COMPOUNDS AND THE USE THEREOF IN THE TREATMENT OF CANCER | Trobio Therapeutics Pty Ltd (AU) | 2022-12-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339866-A1 | Quinazoline compounds and the use thereof in the treatment of cancer | NQO2, TP53, ABL1 | TAAR1 4550/4885HTT 3184/4885KDM4E 2051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.