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SCHEMBL26648341

SCHEMBL26648341

CC1(C)CCC(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(NCCCN5CCN(CCCCCCC(=O)O)CC5)c(S(=O)(=O)C(F)(F)F)c4)c(Oc4cnc5[nH]ccc5c4)c3)CC2)=C(c2ccc(Cl)cc2)C1

nearest known ligand 0.84

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ BCL2 P10415 15/20 0.84
▸ HDAC1 Q13547 3/20 0.73
▸ HDAC6 Q9UBN7 3/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31450990 1.00 BCL2 (0.84) BCL2HDAC1HDAC6
SCHEMBL31450972 0.99 BCL2 (0.82) BCL2HDAC1HDAC6
SCHEMBL26647909 0.99 BCL2 (0.82) BCL2HDAC1HDAC6
SCHEMBL26648300 0.97 BCL2 (0.81) BCL2HDAC1HDAC6
SCHEMBL26648251 0.97 BCL2 (0.81) BCL2HDAC1HDAC6
SCHEMBL31450898 0.97 BCL2 (0.81) BCL2HDAC1HDAC6
SCHEMBL31451009 0.97 BCL2 (0.81) BCL2HDAC1HDAC6
SCHEMBL26647903 0.96 BCL2 (0.85) BCL2HDAC1HDAC6
SCHEMBL31451053 0.96 BCL2 (0.85) BCL2HDAC1HDAC6
SCHEMBL31450794 0.95 BCL2 (0.83) BCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023220425-A1 BCL-XL/BCL-2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2023-11-16 — — WO disclosed
WO-2023220425-A1 BCL-XL/BCL-2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2023-11-16 — — WO disclosed
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