SCHEMBL2664997

SCHEMBL2664997

O=C(/C=C/c1ccc(-c2ccccc2)cc1)c1ccc(Cl)cc1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 10/20 0.81
CYP1B1 Q16678 4/20 0.81
CXCL12 P48061 2/20 0.69
MAOA P21397 4/20 0.67
MAPT P10636 2/20 0.61
PLIN1 O60240 1/20 0.61
LMNA P02545 1/20 0.61
BCHE P06276 1/20 0.61
TNFRSF1A P19438 1/20 0.61
ACHE P22303 1/20 0.61
RECQL P46063 1/20 0.61
PLIN5 Q00G26 1/20 0.61
ABHD5 Q8WTS1 1/20 0.61
CYP1A1 P04798 1/20 0.58
CYP1A2 P05177 1/20 0.58
CYP3A4 P08684 2/20 0.58
HSPD1 P10809 2/20 0.58
HSPE1 P61604 2/20 0.58
KMT2A Q03164 2/20 0.58
RELA Q04206 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL657311 1.00 MAOB (0.81) MAOBCYP1B1CXCL12MAOAMAPT
SCHEMBL657312 1.00 MAOB (0.81) MAOBCYP1B1CXCL12MAOAMAPT
SCHEMBL2648476 1.00 MAOB (0.81) MAOBCYP1B1CXCL12MAOAMAPT
Hydrochloric Acid SCHEMBL11820893 0.98 MAOB (0.79) MAOBCYP1B1CXCL12MAOAMAPT
Hydrochloric Acid SCHEMBL11820886 0.98 MAOB (0.79) MAOBCYP1B1CXCL12MAOAMAPT
Bromide SCHEMBL11821122 0.98 MAOB (0.79) MAOBCYP1B1CXCL12MAOAMAPT
Bromide SCHEMBL11821117 0.98 MAOB (0.79) MAOBCYP1B1CXCL12MAOAMAPT
Bromide SCHEMBL11818763 0.98 MAOB (0.79) MAOBCYP1B1CXCL12MAOAMAPT
Bromide SCHEMBL11818757 0.98 MAOB (0.79) MAOBCYP1B1CXCL12MAOAMAPT
SCHEMBL976912 0.92 CYP1B1 (0.71) MAOBCYP1B1MAOAMAPTPLIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003048109-A1 NOVEL GLUCAGON ANTAGONISTS NOVO NORDISK A/S (DK) 2003-06-12 WO disclosed
US-3931152-A ANTITUBERCULAR AMERICAN CYANAMID COMPANY (US) 1976-01-06 US disclosed