Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 15/20 | 0.37 |
| ▸ | SMARCA2 | P51531 | 11/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 11/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 7/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26653880 | 1.00 | PBRM1 (0.37) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL26653899 | 1.00 | PBRM1 (0.37) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL30658053 | 0.86 | SMARCA2 (0.51) | PBRM1SMARCA2SMARCA4SMN1; SMN2BRD4 | |
| SCHEMBL26654155 | 0.86 | SMARCA2 (0.51) | PBRM1SMARCA2SMARCA4SMN1; SMN2BRD4 | |
| SCHEMBL30657990 | 0.86 | SMARCA2 (0.51) | PBRM1SMARCA2SMARCA4SMN1; SMN2BRD4 | |
| SCHEMBL26654143 | 0.82 | SMARCA2 (0.53) | PBRM1SMARCA2SMARCA4SMN1; SMN2MAPT | |
| SCHEMBL26654239 | 0.79 | PBRM1 (0.42) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL26653968 | 0.77 | IKBKB (0.39) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL26654141 | 0.77 | IKBKB (0.39) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 | |
| SCHEMBL26654149 | 0.77 | IKBKB (0.39) | PBRM1SMARCA2SMARCA4NR1I2NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023220134-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |