SCHEMBL2665460

SCHEMBL2665460

O=C(NCC(F)C(=O)O)c1ccc(CN(C(=O)Nc2ccc(F)c(C(F)(F)F)c2)c2ccc(C3CCCCC3)cc2)cc1

nearest known ligand 0.70

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
GCGR P47871 20/20 0.70
GIPR P48546 18/20 0.70
GLP1R P43220 3/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2665529 0.93 GCGR (0.82) GCGRGIPRGLP1R
SCHEMBL2665556 0.92 GCGR (0.69) GCGRGIPRGLP1R
SCHEMBL2665550 0.92 GCGR (0.69) GCGRGIPRGLP1R
SCHEMBL2665549 0.92 GCGR (0.67) GCGRGIPRGLP1R
SCHEMBL9071838 0.88 GCGR (0.74) GCGRGIPRGLP1R
SCHEMBL2665778 0.87 GCGR (0.70) GCGRGIPRGLP1R
SCHEMBL9071846 0.87 GCGR (0.74) GCGRGIPRGLP1R
SCHEMBL2665542 0.87 GCGR (0.61) GCGRGIPRGLP1R
SCHEMBL2665780 0.87 GCGR (0.69) GCGRGIPRGLP1R
SCHEMBL9071779 0.86 GCGR (0.84) GCGRGIPRGLP1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002000612-A1 GLUCAGON ANTAGONISTS/INVERSE AGONISTS NOVO NORDISK A/S (DK) 2002-01-03 WO disclosed