SCHEMBL2665670

SCHEMBL2665670

CC(C)(C)C1CCC(N(Cc2ccc(C(=O)NCC(F)C(=O)O)cc2)C(=O)Nc2ccc3c(c2)C(F)(F)OC(F)(F)O3)CC1

nearest known ligand 0.57

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GCGR P47871 19/20 0.57
GIPR P48546 8/20 0.57
GLP1R P43220 3/20 0.57
ADCY6 O43306 1/20 0.49
ADCY3 O60266 1/20 0.49
ADCY9 O60503 1/20 0.49
ADCY5 O95622 1/20 0.49
ADCY8 P40145 1/20 0.49
ADCY7 P51828 1/20 0.49
ADCY2 Q08462 1/20 0.49
ADCY1 Q08828 1/20 0.49
ADCY4 Q8NFM4 1/20 0.49
UBE2M P61081 1/20 0.43
DCUN1D1 Q96GG9 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2653372 0.93 GCGR (0.67) GCGRGIPRGLP1RADCY6ADCY3
SCHEMBL9071318 0.88 GCGR (0.54) GCGRGIPRGLP1RADCY6ADCY3
SCHEMBL2665672 0.83 GCGR (0.66) GCGRGIPRGLP1R
SCHEMBL2663318 0.83 GCGR (0.65) GCGRGIPR
SCHEMBL2665674 0.82 GCGR (0.75) GCGRGIPRGLP1RADCY6ADCY3
SCHEMBL2665598 0.81 GCGR (0.83) GCGRGIPRGLP1RADCY6ADCY3
SCHEMBL2665543 0.81 GCGR (0.85) GCGRGIPRGLP1RADCY6ADCY3
SCHEMBL2645043 0.80 GCGR (0.43) GCGRGIPRGLP1RADCY6ADCY3
SCHEMBL2651815 0.80 GCGR (0.43) GCGRGIPRGLP1RADCY6ADCY3
SCHEMBL2665675 0.80 GCGR (0.66) GCGRGIPRGLP1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002000612-A1 GLUCAGON ANTAGONISTS/INVERSE AGONISTS NOVO NORDISK A/S (DK) 2002-01-03 WO disclosed