Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.81 |
| ▸ | GCK | P35557 | 13/20 | 0.75 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2659470 | 1.00 | KCNH2 (0.81) | KCNH2GCKGAATHRBFFAR2 | |
| SCHEMBL2642114 | 1.00 | KCNH2 (0.81) | KCNH2GCKGAATHRBFFAR2 | |
| SCHEMBL2642116 | 1.00 | KCNH2 (0.81) | KCNH2GCKGAATHRBFFAR2 | |
| SCHEMBL2647237 | 0.90 | KCNH2 (1.00) | KCNH2GCKGAATHRBFFAR2 | |
| SCHEMBL2647239 | 0.90 | KCNH2 (1.00) | KCNH2GCKGAATHRBFFAR2 | |
| SCHEMBL2662844 | 0.90 | KCNH2 (1.00) | KCNH2GCKGAATHRBFFAR2 | |
| SCHEMBL2642782 | 0.87 | KCNH2 (0.74) | KCNH2GCKGAATHRBFFAR2 | |
| SCHEMBL2642783 | 0.87 | KCNH2 (0.74) | KCNH2GCKGAATHRBFFAR2 | |
| SCHEMBL2642181 | 0.87 | KCNH2 (0.85) | KCNH2GCK | |
| SCHEMBL2642219 | 0.87 | GCK (0.90) | KCNH2GCKGAATHRBFFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003095438-A9 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2004-12-23 | — | — | WO | disclosed |