SCHEMBL2666720

SCHEMBL2666720

C=S(C)(=O)CCNC(=O)c1ccc(Oc2cc(OC(C)C)cc(C(=O)Nc3nccs3)c2)cc1

nearest known ligand 0.71

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCK P35557 20/20 0.71
KCNH2 Q12809 2/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2659163 0.93 GCK (0.73) GCKKCNH2
SCHEMBL2657760 0.88 GCK (0.69) GCKKCNH2
SCHEMBL2658827 0.87 GCK (0.68) GCKKCNH2
SCHEMBL2658597 0.83 GCK (1.00) GCKKCNH2
SCHEMBL2657597 0.83 GCK (0.75) GCKKCNH2
SCHEMBL2658812 0.83 GCK (0.67) GCKKCNH2
SCHEMBL2658654 0.82 GCK (0.66) GCKKCNH2
SCHEMBL2657877 0.82 GCK (0.77) GCKKCNH2
SCHEMBL2658987 0.82 GCK (0.63) GCKKCNH2
SCHEMBL3603143 0.81 GCK (0.75) GCKKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005080360-A1 COMPOUNDS ASTRAZENECA AB (SE) 2005-09-01 WO disclosed