Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 20/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12782124 | 1.00 | GCK (0.61) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL2667114 | 0.90 | GCK (0.63) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL1426943 | 0.90 | GCK (0.73) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL320649 | 0.90 | GCK (0.73) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL2662756 | 0.90 | GCK (0.73) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL1107723 | 0.90 | GCK (0.67) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL1427036 | 0.88 | GCK (0.61) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL1427000 | 0.86 | GCK (0.61) | GCKKCNH2 | |
| SCHEMBL1427113 | 0.85 | GCK (0.53) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL2661628 | 0.84 | GCK (0.85) | GCKCYP1A2ABCB1CYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007007041-A1 | HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |