Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 15/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2667123 | 0.91 | GCK (0.40) | GCKKCNH2 | |
| SCHEMBL9072484 | 0.90 | PARP10 (0.40) | GCKKCNH2F2PRSS1PRSS2 | |
| SCHEMBL1775968 | 0.82 | GCK (0.45) | GCKKCNH2 | |
| SCHEMBL1774528 | 0.82 | GCK (0.62) | GCKKCNH2 | |
| SCHEMBL1776155 | 0.81 | KMT2A (0.39) | GCKKCNH2 | |
| SCHEMBL1775951 | 0.81 | GCK (0.63) | GCKKCNH2 | |
| SCHEMBL1775822 | 0.80 | MAPT (0.39) | GCKKCNH2 | |
| SCHEMBL1776886 | 0.76 | GCK (0.64) | GCKKCNH2 | |
| SCHEMBL1775725 | 0.75 | GCK (0.63) | GCKKCNH2 | |
| SCHEMBL1775310 | 0.74 | GCK (0.48) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006125972-A1 | HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | disclosed |