Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 18/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12781656 | 0.98 | GCK (0.59) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL1377401 | 0.89 | GCK (0.79) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL2667094 | 0.89 | GCK (0.59) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL2659386 | 0.88 | GCK (0.78) | GCKKCNH2 | |
| SCHEMBL1376087 | 0.87 | GCK (0.70) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL2667027 | 0.87 | GCK (0.57) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL1427371 | 0.87 | GCK (0.80) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL1427290 | 0.86 | GCK (0.81) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL1427077 | 0.86 | GCK (0.71) | GCKKCNH2CYP1A2ABCB1CYP3A4 | |
| SCHEMBL1426495 | 0.85 | GCK (0.72) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305674-A1 | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes | AstraZeneca AB (SE) | 2011-04-06 | — | — | EP | disclosed |
| EP-2301929-A1 | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes | AstraZeneca AB (Publ) (SE) | 2011-03-30 | — | — | EP | disclosed |
| EP-2301935-A1 | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes | AstraZeneca AB (Publ) (SE) | 2011-03-30 | — | — | EP | disclosed |
| WO-2007007041-A1 | HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |