Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 20/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12811382 | 1.00 | GCK (0.61) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL1426924 | 0.92 | GCK (0.60) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL12781684 | 0.92 | GCK (0.60) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL2669073 | 0.88 | GCK (0.59) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL12783543 | 0.87 | GCK (0.74) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL9072223 | 0.87 | GCK (0.74) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL12782140 | 0.84 | GCK (0.66) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL2661628 | 0.83 | GCK (0.85) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL1426451 | 0.83 | GCK (0.85) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL1426825 | 0.82 | GCK (0.68) | GCKCYP1A2ABCB1CYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007007041-A1 | HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |