Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 3/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | BUB1 | O43683 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1330485 | 0.86 | GCK (0.38) | GCKNPC1RAB9ASMN1; SMN2POLB | |
| Hydrochloric Acid SCHEMBL1329725 | 0.85 | NPC1 (0.38) | GCKNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL1330307 | 0.82 | GCK (0.48) | GCKNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL1328211 | 0.81 | GCK (0.59) | GCKNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL1331411 | 0.77 | NPC1 (0.41) | GCKNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL1330094 | 0.77 | GCK (0.41) | GCKNPC1RAB9ASMN1; SMN2POLB | |
| Hydrochloric Acid SCHEMBL1329610 | 0.76 | NPC1 (0.42) | GCKNPC1RAB9ASMN1; SMN2POLB | |
| Hydrochloric Acid SCHEMBL1331182 | 0.76 | GCK (0.41) | GCKNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL1328103 | 0.76 | GCK (0.49) | GCKNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL2340655 | 0.75 | GCK (0.60) | GCKNPC1RAB9ASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117381-A2 | 2 -AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC. (US) | 2007-10-18 | — | — | WO | disclosed |