Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 20/20 | 0.65 |
| ▸ | GIPR | P48546 | 6/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2667908 | 0.86 | GCGR (0.58) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2667406 | 0.86 | GCGR (0.60) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2667898 | 0.81 | GCGR (0.75) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2251804 | 0.81 | GCGR (0.75) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2253902 | 0.80 | GCGR (0.83) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2667880 | 0.80 | GCGR (0.59) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL9071566 | 0.79 | GCGR (0.75) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL13003046 | 0.79 | GCGR (0.77) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL12360447 | 0.79 | GCGR (0.75) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2667839 | 0.79 | GCGR (0.74) | GCGRGIPRCYP3A4CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590336-B1 | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK SHARP & DOHME (US) | 2010-12-01 | — | — | EP | disclosed |
| WO-2004069158-A2 | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 2004-08-19 | — | — | WO | disclosed |