SCHEMBL26674453

SCHEMBL26674453

COc1ccc2c(cc(C(=O)NC3(c4ccc(C(=O)NSC)cc4)COC3)n2C)c1Cl

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PHGDH O43175 15/20 0.64
WDR91 A4D1P6 5/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19343559 0.87 PHGDH (0.64) PHGDHWDR91
SCHEMBL19343498 0.84 PHGDH (0.61) PHGDHWDR91
SCHEMBL30339572 0.84 PHGDH (0.61) PHGDHWDR91
SCHEMBL19343204 0.83 PHGDH (0.80) PHGDHWDR91
SCHEMBL19343477 0.83 PHGDH (0.61) PHGDH
SCHEMBL19343647 0.83 PHGDH (0.69) PHGDH
SCHEMBL19343590 0.81 PHGDH (0.59) PHGDHWDR91
SCHEMBL19343499 0.81 PHGDH (0.57) PHGDH
SCHEMBL20793883 0.81 PHGDH (0.59) PHGDHWDR91
SCHEMBL19343406 0.81 PHGDH (0.59) PHGDHWDR91

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3884939-B1 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF RAZE THERAPEUTICS INC (US) 2023-10-25 EP disclosed