Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CDK3 | Q00526 | 2/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GRK2 | P25098 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30641314 | 1.00 | KDM4E (0.40) | KDM4EALDH1A1KMT2AMEN1JAK2 | |
| SCHEMBL31437219 | 1.00 | KDM4E (0.40) | KDM4EALDH1A1KMT2AMEN1JAK2 | |
| SCHEMBL26674862 | 0.86 | MAP4K1 (0.39) | CDK2MAP4K1ABL1HAVCR2WEE1 | |
| SCHEMBL30641297 | 0.86 | BTK (0.43) | CDK2MAP4K1ABL1HAVCR2WEE1 | |
| SCHEMBL30641303 | 0.86 | MAP4K1 (0.39) | CDK2MAP4K1ABL1HAVCR2WEE1 | |
| SCHEMBL26674773 | 0.86 | BTK (0.43) | CDK2MAP4K1ABL1HAVCR2WEE1 | |
| SCHEMBL30641348 | 0.82 | KMT2A (0.44) | KDM4EALDH1A1KMT2AMEN1JAK2 | |
| SCHEMBL26674522 | 0.82 | KMT2A (0.44) | KDM4EALDH1A1KMT2AMEN1JAK2 | |
| SCHEMBL31437316 | 0.82 | KMT2A (0.44) | KDM4EALDH1A1KMT2AMEN1JAK2 | |
| SCHEMBL31437308 | 0.82 | HAVCR2 (0.41) | KDM4EALDH1A1KMT2AMEN1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023220831-A1 | HETEROARENES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME | REPARE THERAPEUTICS INC. (CA) | 2023-11-23 | — | — | WO | disclosed |