Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 13/20 | 0.58 |
| ▸ | GRM5 | P41594 | 5/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2667811 | 1.00 | GCK (0.58) | GCKGRM5CYP3A4DRD3SLC6A3 | |
| SCHEMBL2667825 | 0.92 | GRM5 (0.58) | GCKGRM5CYP3A4DRD3SLC6A3 | |
| SCHEMBL9071026 | 0.90 | GRM5 (0.55) | GCKGRM5KCNH2NPC1HPGD | |
| SCHEMBL2667726 | 0.89 | GCK (0.64) | GCKGRM5CYP3A4DRD3SLC6A3 | |
| SCHEMBL2667538 | 0.89 | GCK (0.50) | GCKGRM5KCNH2NPC1RAB9A | |
| SCHEMBL2667580 | 0.89 | GCK (0.50) | GCKGRM5KCNH2NPC1RAB9A | |
| SCHEMBL2667558 | 0.88 | GCK (0.56) | GCKGRM5KCNH2NPC1RAB9A | |
| SCHEMBL2667584 | 0.87 | MAPK1 (0.54) | GCKCYP3A4KCNH2SMN1; SMN2 | |
| SCHEMBL2667545 | 0.87 | GCK (0.54) | GCKGRM5KCNH2HPGDSMN1; SMN2 | |
| SCHEMBL2668013 | 0.86 | GRM5 (0.63) | GCKGRM5NPC1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009083553-A1 | AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS | RHEOSCIENCE A/S (DK) | 2009-07-09 | — | — | WO | disclosed |