Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | GCK | P35557 | 9/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SCD | O00767 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9070872 | 0.86 | NPC1 (0.56) | NPC1RAB9AMAPTGCKSMN1; SMN2 | |
| SCHEMBL2667590 | 0.86 | MAPK1 (0.47) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL9071036 | 0.86 | MAPT (0.52) | NPC1RAB9AMAPTGCKSMN1; SMN2 | |
| SCHEMBL9071034 | 0.86 | MAPT (0.52) | NPC1RAB9AMAPTGCKSMN1; SMN2 | |
| SCHEMBL9071035 | 0.86 | MAPT (0.52) | NPC1RAB9AMAPTGCKSMN1; SMN2 | |
| SCHEMBL2667834 | 0.84 | MAPK1 (0.64) | NPC1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2668013 | 0.84 | GRM5 (0.63) | NPC1RAB9AMAPTGCKSMN1; SMN2 | |
| SCHEMBL2667805 | 0.84 | GRM5 (0.63) | NPC1RAB9AMAPTGCKSMN1; SMN2 | |
| SCHEMBL2667489 | 0.83 | GRM5 (0.50) | NPC1RAB9AMAPTGCKSMN1; SMN2 | |
| SCHEMBL2667609 | 0.83 | GCK (0.58) | NPC1RAB9AMAPTGCKSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009083553-A1 | AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS | RHEOSCIENCE A/S (DK) | 2009-07-09 | — | — | WO | disclosed |