SCHEMBL2667698

SCHEMBL2667698

COC[C@@H](C)Oc1cc(C(=O)Nc2ccc(CC(=O)OC)cn2)cc(Oc2cccc(C)c2)n1

nearest known ligand 0.54

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GCK P35557 20/20 0.54
RARA P10276 1/20 0.50
RARB P10826 1/20 0.50
RARG P13631 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2667562 0.92 GCK (0.47) GCKRARARARBRARG
SCHEMBL2667795 0.91 GCK (0.64) GCKRARARARBRARG
SCHEMBL2667823 0.88 GCK (0.69) GCKRARARARBRARG
SCHEMBL9071028 0.88 GCK (0.61) GCKRARARARBRARG
SCHEMBL9071062 0.87 GCK (0.63) GCKRARARARBRARG
SCHEMBL2667575 0.87 GCK (0.60) GCKRARARARBRARG
SCHEMBL2667809 0.86 GCK (0.53) GCKRARARARBRARG
SCHEMBL2668006 0.85 GCK (0.51) GCKRARARARBRARG
SCHEMBL2667773 0.85 GCK (0.53) GCKRARARARBRARG
SCHEMBL2667644 0.85 GCK (0.64) GCKRARARARBRARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009083553-A1 AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS RHEOSCIENCE A/S (DK) 2009-07-09 WO disclosed