Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 19/20 | 0.57 |
| ▸ | GIPR | P48546 | 7/20 | 0.57 |
| ▸ | DDHD2 | O94830 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2254559 | 0.85 | GCGR (0.78) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2667524 | 0.85 | GCGR (0.78) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL9071594 | 0.78 | GCGR (0.57) | GCGRGIPRDDHD2KCNH2 | |
| SCHEMBL2250235 | 0.78 | GCGR (0.73) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL12360090 | 0.78 | GCGR (0.73) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2667889 | 0.77 | GCGR (0.76) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2667329 | 0.77 | GCGR (0.79) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL9071595 | 0.74 | GCGR (0.70) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2667420 | 0.74 | GCGR (0.74) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2253945 | 0.74 | GCGR (0.74) | GCGRGIPRCYP3A4CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590336-B1 | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK SHARP & DOHME (US) | 2010-12-01 | — | — | EP | disclosed |
| WO-2004069158-A2 | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 2004-08-19 | — | — | WO | disclosed |