Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 13/20 | 0.41 |
| ▸ | DHFR | P00374 | 2/20 | 0.37 |
| ▸ | DCPS | Q96C86 | 2/20 | 0.37 |
| ▸ | IKBKB | O14920 | 3/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | RARA | P10276 | 1/20 | 0.32 |
| ▸ | RARB | P10826 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2086086 | 0.87 | GCK (0.39) | GCKRARARARB | |
| SCHEMBL2087030 | 0.84 | GCK (0.46) | GCKRARARARB | |
| SCHEMBL2086747 | 0.82 | PRMT5 (0.41) | GCKRARARARB | |
| SCHEMBL2668031 | 0.82 | GCK (0.37) | GCKDHFRDCPSRARARARB | |
| SCHEMBL2087531 | 0.82 | GCK (0.41) | GCKDHFRDCPSRARARARB | |
| SCHEMBL2668060 | 0.81 | GCK (0.42) | GCKKCNH2 | |
| SCHEMBL2086632 | 0.81 | GCK (0.42) | GCKKCNH2 | |
| SCHEMBL2086592 | 0.81 | GCK (0.42) | GCKKCNH2 | |
| SCHEMBL708895 | 0.80 | GCK (0.52) | GCKKCNH2 | |
| SCHEMBL2086661 | 0.80 | GCK (0.51) | GCKRARARARBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006125958-A1 | 2-PHENYL SUBSTITUTED IMIDAZOL [4 , 5B] PYRIDINE/ PYRAZINE AND PURINE DERIVATIVES AS GLUCOKINASE MODULATORS | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | disclosed |