Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 18/20 | 0.51 |
| ▸ | RARG | P13631 | 1/20 | 0.46 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2086661 | 1.00 | GCK (0.51) | GCKRARGRARARARBKCNH2 | |
| SCHEMBL2086481 | 0.91 | GCK (0.46) | GCKRARGKCNH2CHEK2 | |
| SCHEMBL2086792 | 0.91 | GCK (0.57) | GCKRARGKCNH2 | |
| SCHEMBL2085921 | 0.90 | GCK (0.45) | GCKRARGKCNH2 | |
| SCHEMBL2087569 | 0.88 | GCK (0.43) | GCKRARGKCNH2 | |
| SCHEMBL2087022 | 0.88 | GCK (0.55) | GCKKCNH2 | |
| SCHEMBL2668037 | 0.88 | GCK (0.55) | GCKKCNH2 | |
| SCHEMBL2087542 | 0.87 | GCK (0.48) | GCKRARGKCNH2 | |
| SCHEMBL2668079 | 0.87 | GCK (0.48) | GCKRARGKCNH2 | |
| SCHEMBL2088823 | 0.86 | GCK (0.45) | GCKRARGKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006125958-A1 | 2-PHENYL SUBSTITUTED IMIDAZOL [4 , 5B] PYRIDINE/ PYRAZINE AND PURINE DERIVATIVES AS GLUCOKINASE MODULATORS | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | disclosed |