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SCHEMBL26680680

SCHEMBL26680680

O=C(NS(=O)(=O)c1ccc(NCCSc2ccccc2)c(C(F)(F)F)c1)c1ccc(N2CCN(Cc3cc(OC(F)(F)F)cc(-c4cncc(O)c4)c3)CC2)nn1

nearest known ligand 0.43

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ BCL2L1 Q07817 16/20 0.43
▸ BCL2 P10415 11/20 0.43
▸ MCL1 Q07820 4/20 0.35
▸ DCTPP1 Q9H773 2/20 0.34
▸ BCL2L2 Q92843 1/20 0.34
▸ SCD O00767 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30687728 0.94 BCL2L1 (0.42) BCL2L1BCL2MCL1DCTPP1BCL2L2
SCHEMBL26681972 0.94 BCL2L1 (0.42) BCL2L1BCL2MCL1DCTPP1BCL2L2
SCHEMBL26680398 0.93 BCL2L1 (0.42) BCL2L1BCL2MCL1DCTPP1BCL2L2
SCHEMBL26682415 0.93 BCL2L1 (0.43) BCL2L1BCL2MCL1DCTPP1BCL2L2
SCHEMBL26680478 0.93 BCL2L1 (0.41) BCL2L1BCL2MCL1DCTPP1BCL2L2
SCHEMBL30687862 0.93 BCL2L1 (0.43) BCL2L1BCL2MCL1DCTPP1BCL2L2
SCHEMBL26683171 0.92 BCL2L1 (0.44) BCL2L1BCL2MCL1DCTPP1BCL2L2
SCHEMBL26681429 0.92 BCL2L1 (0.46) BCL2L1BCL2MCL1
SCHEMBL26680897 0.90 BCL2L1 (0.41) BCL2L1BCL2MCL1DCTPP1BCL2L2
SCHEMBL30687876 0.90 BCL2L1 (0.42) BCL2L1BCL2MCL1DCTPP1BCL2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4279476-A1 METHOD FOR ALKYLATING ACIDIC FUNCTIONAL GROUP CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-11-22 — — EP disclosed
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