Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.47 |
| ▸ | CDK8 | P49336 | 2/20 | 0.47 |
| ▸ | CLK2 | P49760 | 2/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660923 | 0.85 | JAK2 (0.62) | GSK3BGSK3ACLK4DAPK3PRKD3 | |
| SCHEMBL2661688 | 0.82 | MAPT (0.51) | GSK3BGSK3ACLK4DAPK3PRKD3 | |
| SCHEMBL2661437 | 0.76 | GSK3A (0.54) | GSK3BGSK3ACDK2CDK7CDC7 | |
| SCHEMBL2660578 | 0.76 | GSK3B (0.46) | GSK3BGSK3ADYRK1ACDK2SMN1; SMN2 | |
| SCHEMBL5929451 | 0.75 | KDM4E (0.48) | CDK2TRPA1SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL2661388 | 0.75 | CDK7 (0.44) | GSK3BGSK3ACLK4DAPK3PRKD3 | |
| SCHEMBL2661291 | 0.75 | CDC7 (0.41) | GSK3BGSK3ACLK4DAPK3PRKD3 | |
| SCHEMBL2661883 | 0.74 | GSK3B (0.54) | GSK3BGSK3ACLK4DAPK3MAPK8 | |
| SCHEMBL2661306 | 0.74 | LRRK2 (0.45) | GSK3BGSK3ACLK4DAPK3PRKD3 | |
| SCHEMBL2660239 | 0.74 | AXL (0.54) | GSK3BCLK2DYRK1APRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156757-A1 | INDAZOLE COMPOUNDS FOR ACTIVATING GLUCOKINASE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-24 | — | — | WO | disclosed |