Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 8/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | FABP2 | P12104 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3372781 | 0.84 | PPARA (0.66) | PPARACYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL626124 | 0.80 | PPARA (0.70) | PPARACYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL31117862 | 0.78 | PPARA (0.70) | PPARACYP3A4CYP1A2ALDH1A1HTR2A | |
| SCHEMBL2668320 | 0.77 | PPARA (0.40) | PPARACYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL11639708 | 0.76 | PPARA (0.64) | PPARACYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL11813157 | 0.76 | CYP1A2 (0.46) | PPARACYP1A2CYP2C19MEN1MAPT | |
| SCHEMBL6764273 | 0.75 | HSP90AA1 (0.48) | MEN1KMT2AHSP90AA1KDM4EALDH1A1 | |
| SCHEMBL7348145 | 0.75 | PPARA (0.39) | PPARACYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL4000649 | 0.74 | PPARA (0.47) | PPARACYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL3948925 | 0.74 | PPARA (0.47) | PPARACYP3A4CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125735-B1 | 2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION | ADVINUS THERAPEUTICS PRIVATE LTD (IN) | 2012-06-27 | — | — | EP | disclosed |
| WO-2008104994-A2 | 2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2008-09-04 | — | — | WO | disclosed |