Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 8/20 | 0.37 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
| ▸ | PKD1 | P98161 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26684169 | 0.93 | MAP3K14 (0.42) | MAP3K14JAK1JAK3JAK2PIM1 | |
| SCHEMBL30668038 | 0.93 | MAP3K14 (0.42) | MAP3K14JAK1JAK3JAK2PIM1 | |
| SCHEMBL30668002 | 0.90 | JAK3 (0.36) | MAP3K14JAK1JAK3JAK2BTK | |
| SCHEMBL26684460 | 0.87 | MAP3K14 (0.36) | MAP3K14 | |
| SCHEMBL26684882 | 0.87 | MAP3K14 (0.37) | MAP3K14 | |
| SCHEMBL26684684 | 0.83 | MAP3K14 (0.42) | MAP3K14PKD1 | |
| SCHEMBL26684153 | 0.82 | MAP3K14 (0.35) | MAP3K14PKD1 | |
| SCHEMBL26684200 | 0.82 | MAP3K14 (0.41) | MAP3K14PKD1 | |
| SCHEMBL26684252 | 0.81 | MAP3K14 (0.40) | MAP3K14PKD1 | |
| SCHEMBL26684609 | 0.81 | MAP3K14 (0.40) | MAP3K14PKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023217906-A1 | PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-16 | — | — | WO | disclosed |