SCHEMBL26686209

SCHEMBL26686209

Nc1n[nH]c2ccc(-c3ccnc(NC(=O)Nc4cccc(Oc5ccccc5)c4)c3)cc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FLT1 P17948 3/20 0.47
▸ TEK Q02763 1/20 0.47
▸ JAK2 O60674 5/20 0.46
▸ GCK P35557 1/20 0.46
▸ EGFR P00533 2/20 0.46
▸ BTK Q06187 1/20 0.46
▸ KDR P35968 7/20 0.46
▸ MAPK1 P28482 1/20 0.46
▸ JAK1 P23458 2/20 0.45
▸ PLK4 O00444 2/20 0.45
▸ AURKA O14965 2/20 0.45
▸ ROCK2 O75116 2/20 0.45
▸ CHEK2 O96017 2/20 0.45
▸ NTRK1 P04629 2/20 0.45
▸ LCK P06239 2/20 0.45
▸ CSF1R P07333 2/20 0.45
▸ LYN P07948 2/20 0.45
▸ KIT P10721 2/20 0.45
▸ FLT4 P35916 2/20 0.45
▸ FLT3 P36888 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30633357 1.00 FLT1 (0.47) FLT1TEKJAK2GCKEGFR
SCHEMBL30633297 0.89 MEN1 (0.48) JAK2KDRMAPK1JAK1KIT
SCHEMBL26686298 0.89 MEN1 (0.48) JAK2KDRMAPK1JAK1KIT
SCHEMBL30633352 0.89 JAK2 (0.56) FLT1JAK2EGFRKDRMAPK1
SCHEMBL26685861 0.89 JAK2 (0.56) FLT1JAK2EGFRKDRMAPK1
SCHEMBL31240330 0.88 JAK2 (0.50) JAK2EGFRBTKKDRJAK1
SCHEMBL31420124 0.85 JAK2 (0.61) FLT1JAK2EGFRKDRMAPK1
SCHEMBL26686370 0.85 JAK2 (0.61) FLT1JAK2EGFRKDRMAPK1
SCHEMBL30633302 0.85 F10 (0.46) FLT1JAK2EGFRKDRMAPK1
SCHEMBL26686210 0.85 F10 (0.46) FLT1JAK2EGFRKDRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4705291-A1 IKK-ALPHA INHIBITORS Cancer Research Technology Limited (GB) 2026-03-11 — — EP claimed
US-20250304576-A1 IKK INHIBITORS CANCER RESEARCH TECH LTD (GB) 2025-10-02 — — US claimed
EP-4522597-A1 IKK INHIBITORS Cancer Research Technology Limited (GB) 2025-03-19 — — EP claimed
WO-2024228035-A1 IKK-ALPHA INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-11-07 — — WO claimed
WO-2023218201-A1 IKK INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2023-11-16 — — WO claimed
EP-4705291-A1 IKK-ALPHA INHIBITORS Cancer Research Technology Limited (GB) 2026-03-11 — — EP disclosed
US-20250304576-A1 IKK INHIBITORS CANCER RESEARCH TECH LTD (GB) 2025-10-02 — — US disclosed
EP-4522597-A1 IKK INHIBITORS Cancer Research Technology Limited (GB) 2025-03-19 — — EP disclosed
WO-2024228035-A1 IKK-ALPHA INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-11-07 — — WO disclosed
WO-2023218201-A1 IKK INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2023-11-16 — — WO disclosed
WO-2023218201-A1 IKK INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2023-11-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250304576-A1 IKK INHIBITORS NFKBIA, IKBKE, IKBKB FLT1 1500/4885TEK 3025/4885JAK2 207/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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