Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 15/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1107721 | 0.90 | GCK (0.55) | GCKMAPTKCNH2 | |
| SCHEMBL2651431 | 0.90 | GCK (0.53) | GCKMAPTKCNH2 | |
| SCHEMBL9071287 | 0.88 | GCK (0.49) | GCKKCNH2MMP14 | |
| SCHEMBL1107748 | 0.85 | GCK (0.50) | GCKKCNH2 | |
| SCHEMBL3603132 | 0.83 | GCK (0.48) | GCKKCNH2MMP14MMP3 | |
| SCHEMBL1107717 | 0.81 | CYP2C9 (0.49) | GCKMAPTRAB9A | |
| SCHEMBL1107725 | 0.81 | GCK (0.46) | GCKKCNH2 | |
| SCHEMBL1989863 | 0.80 | MAPT (0.54) | MAPTRAB9A | |
| SCHEMBL2656511 | 0.80 | HPGD (0.52) | GCKRAB9A | |
| SCHEMBL2668959 | 0.80 | RARB (0.54) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008005964-A2 | PHOSPHONATE AND PHOSPHINATE COMPOUNDS AS GLUCOKINASE ACTIVATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-10 | — | — | WO | disclosed |