Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 16/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1378805 | 0.85 | GCK (0.72) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL14173451 | 0.83 | GCK (0.61) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL9892948 | 0.82 | GCK (0.67) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL1107723 | 0.82 | GCK (0.67) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL1107293 | 0.81 | GCK (0.66) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL1107651 | 0.80 | GCK (0.68) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL12782140 | 0.77 | GCK (0.66) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL1492818 | 0.76 | GCK (0.78) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL1381418 | 0.74 | GCK (0.58) | GCKCYP1A2ABCB1CYP3A4CYP2C8 | |
| SCHEMBL12811687 | 0.74 | GCK (0.66) | GCKCYP1A2ABCB1CYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075073-A1 | NOVEL CRYSTALLINE COMPOUND USEFUL AS GLK ACTIVATOR | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |