Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 15/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL642946 | 0.78 | GCK (0.53) | GCKKCNH2NPC1RAB9AKDM4E | |
| SCHEMBL643430 | 0.72 | GCK (0.62) | GCKKCNH2NPC1RAB9A | |
| SCHEMBL10253008 | 0.70 | GCK (0.66) | GCKKCNH2NPC1RAB9A | |
| SCHEMBL2645161 | 0.67 | GCK (0.59) | GCKKCNH2NPC1RAB9AKDM4E | |
| SCHEMBL643580 | 0.67 | GCK (0.53) | GCKKCNH2NPC1RAB9AKDM4E | |
| SCHEMBL645243 | 0.67 | GCK (0.81) | GCKKCNH2 | |
| SCHEMBL644067 | 0.67 | GCK (0.68) | GCKKCNH2NPC1RAB9A | |
| SCHEMBL642311 | 0.66 | GCK (0.65) | GCKKCNH2NPC1RAB9AKDM4E | |
| SCHEMBL2644001 | 0.66 | GCK (0.60) | GCKKCNH2NPC1RAB9A | |
| SCHEMBL643724 | 0.66 | GCK (0.64) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007122482-A1 | FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES | PFIZER PRODUCTS INC. (US) | 2007-11-01 | — | — | WO | disclosed |