Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.70 |
| ▸ | FLT1 | P17948 | 3/20 | 0.69 |
| ▸ | FLT4 | P35916 | 3/20 | 0.69 |
| ▸ | CSF1R | P07333 | 2/20 | 0.68 |
| ▸ | BRAF | P15056 | 3/20 | 0.66 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.60 |
| ▸ | RAF1 | P04049 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26697224 | 0.93 | KDR (0.79) | KDRFLT1FLT4CSF1RBRAF | |
| SCHEMBL26697330 | 0.89 | KDR (0.73) | KDRFLT1FLT4CSF1RBRAF | |
| SCHEMBL26697219 | 0.88 | KDR (0.78) | KDRFLT1FLT4CSF1RBRAF | |
| SCHEMBL5202106 | 0.86 | KDR (0.74) | KDRFLT1FLT4CSF1RBRAF | |
| SCHEMBL26697268 | 0.86 | KDR (0.70) | KDRFLT1FLT4BRAFPDGFRA | |
| SCHEMBL5208126 | 0.85 | KDR (0.75) | KDRFLT1FLT4CSF1RBRAF | |
| SCHEMBL26697251 | 0.84 | KDR (0.70) | KDRFLT1FLT4CSF1RBRAF | |
| SCHEMBL26697316 | 0.84 | KDR (0.78) | KDRFLT1FLT4CSF1RBRAF | |
| SCHEMBL26697275 | 0.84 | KDR (0.68) | KDRFLT1FLT4BRAFPDGFRA | |
| SCHEMBL26697290 | 0.84 | KDR (0.76) | KDRFLT1FLT4CSF1RBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114920703-B | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2024-01-09 | — | — | CN | disclosed |
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| CN-114920703-A | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2022-08-19 | — | — | CN | disclosed |