Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.75 |
| ▸ | FLT1 | P17948 | 5/20 | 0.75 |
| ▸ | FLT4 | P35916 | 5/20 | 0.75 |
| ▸ | BRAF | P15056 | 12/20 | 0.70 |
| ▸ | RAF1 | P04049 | 6/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26697210 | 0.94 | KDR (0.73) | KDRFLT1FLT4BRAF | |
| SCHEMBL26697292 | 0.91 | KDR (0.75) | KDRFLT1FLT4BRAFRAF1 | |
| SCHEMBL26697235 | 0.90 | KDR (0.73) | KDRFLT1FLT4BRAF | |
| SCHEMBL26697249 | 0.88 | KDR (0.72) | KDRFLT1FLT4BRAFRAF1 | |
| SCHEMBL26894823 | 0.88 | KDR (0.67) | KDRFLT1FLT4BRAF | |
| SCHEMBL26697214 | 0.88 | KDR (0.74) | KDRFLT1FLT4BRAFRAF1 | |
| SCHEMBL26697248 | 0.88 | KDR (0.73) | KDRFLT1FLT4BRAFRAF1 | |
| SCHEMBL29757938 | 0.87 | KDR (0.65) | KDRFLT1FLT4BRAF | |
| SCHEMBL26894877 | 0.87 | KDR (0.65) | KDRFLT1FLT4BRAF | |
| SCHEMBL26894914 | 0.86 | KDR (0.76) | KDRFLT1FLT4BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114920703-B | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2024-01-09 | — | — | CN | disclosed |
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| CN-114920703-A | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2022-08-19 | — | — | CN | disclosed |